Mainframe devices can be rebooted for various reasons. While a device is rebooting, it is temporarily disabled, and a “reboot timer” is visible in the Incognita view showing the number of turns until the device finishes rebooting.

Devices can be rebooted by EMP Packs or Dr. Xu's Subdermal Tools, by the daemons Echo and Failsafe, by the program Fool, by being in range of a Modded guard, or by scripted events in Cybernetics Lab and Nanofab Vestibule missions. Additionally, drones reboot after being hacked and controlled, and Emitters reboot when walked through in some circumstances.